Audience: Clinicians. Published 12 November 2026 (AEDT). Source updated 11 November 2026.
What changed
The TGA’s 11 November update extends the estimated shortage of Estradot 25, 50, 75 and 100 to 30 June 2027 (previously 31 December 2026) and Estraderm MX 100 to 30 November 2026 (previously 30 October 2026). Estradot 37.5, Estraderm MX 25/50/75 and all Estalis Sequi and Continuous presentations are listed as resolved. Dates are supplier estimates and may change.
Practical implications
- The TGA asks prescribers to consider the shortage when initiating transdermal HRT, to preserve supply for existing patients.
- The estradiol Serious Scarcity Substitution Instrument lets pharmacists substitute the same strength in another brand, or two same-brand packs of half strength worn together, without prescriber pre-approval. The Federal Register currently lists it as ceasing on 28 February 2027, before the projected Estradot recovery date, unless extended.
- Section 19A overseas-registered estradiol patches are PBS-subsidised. Estramon (24-patch packs) is not PBS-subsidised when dispensed under the instrument; a new prescription is needed for subsidy. Estraderm MX 75 is not PBS-listed.
- Patients should not cut patches. Adhesive differences may cause skin reactions, and patients may need instruction on applying two patches.
Where substitution is unsuitable or unavailable, the TGA notes oral, gel and vaginal options; choice and dosing equivalence remain an individual clinical decision.
Limitations
This is regulator supply-management information, not comparative efficacy or safety evidence. Local stock varies; recheck the TGA notice and Medicine Shortage Reports Database. Trial appraisal, funding and conflict review are not applicable.
Prepared with AI assistance from the linked official sources; not individually reviewed by a clinician. General information only, not individual medical advice.
Sources
TGA: About the shortage of transdermal HRT patches (updated 11 November 2026; accessed 12 November 2026, AEDT).
Federal Register of Legislation: Estradiol Serious Scarcity Substitution Instrument 2024 (accessed 12 November 2026, AEDT).